Based on politics/religion alone, Candace and I wouldn't see eye to eye that's for sure. lol My political views are "radical" considering what's mainstream but then I don't consider them radical simply because to a point I think a lot of the western political philosophers that have contributed to western politics are full of it. I think Candace and I could get along in other areas though.
I would imagine Mary-Kate might seem unlikeable if you look at the paparazzi photos and then that rather unfortunate but understandable footage of her flipping a papparazzo the bird. I don't pay any attention to the papparazzi though. I think being followed around by them constantly would make anyone play the "get out of my face" card. It would understandably make anyone unpleasant.
Jodie, on meth, probably wouldn't work since meth is kind of known to turn people into monumental jerks to put it mildly.
As for Bob, I think his dirty jokes wouldn't really reflect how he is in person unless he's actually like that all the time which I really can't imagine. lol